That does look high-ish miles for a 14 plate S5. S and RS models do tend to be mostly enthusiasts and a 'toy', so in general they are usually quite low miles, but that is a general assumption. 
In May 2014 the engine was revised quite heavily. Still a supercharged 3.0 v6 and both pre and post are considered good reliable engines. Also the DSG gearbox is on the 3rd gen, I think so the common issues with sensors and mechatronics have been resolved and they normally don't give issues if serviced every 40k miles (35k first service).
So long as serviced well and regularly then yes they are good at those miles.
Also, I would go for full MMI which will have the buttons and knobs around the gear selector, but I guess this does have that as it has the dynamic ride and pano roof, but not a given.
Engine issues can be thermostat, water pump, crank pulley and sometimes timing chains, but this can be due to poor servicing.
Also these are very tunable so a lot can be tuned. 450bhp from a simple remap is very attainable! But this doesn't mean it's been thrashed, as said, a lot of owner like on here are enthusiasts so look after their car.
There can be lemons out there, but they do tend to have a sketchy past, like insurance write offs, so so long as you do proper checks or buy from a decent dealer, you should be good. Plenty of tuners, specialists around and forums like these, so if you are unfortunate to have a problem, it usually can be sorted without paying through the nose at the dealers.
In May 2014 the engine was revised quite heavily. Still a supercharged 3.0 v6 and both pre and post are considered good reliable engines. Also the DSG gearbox is on the 3rd gen, I think so the common issues with sensors and mechatronics have been resolved and they normally don't give issues if serviced every 40k miles (35k first service).
So long as serviced well and regularly then yes they are good at those miles.
Also, I would go for full MMI which will have the buttons and knobs around the gear selector, but I guess this does have that as it has the dynamic ride and pano roof, but not a given.
Engine issues can be thermostat, water pump, crank pulley and sometimes timing chains, but this can be due to poor servicing.
Also these are very tunable so a lot can be tuned. 450bhp from a simple remap is very attainable! But this doesn't mean it's been thrashed, as said, a lot of owner like on here are enthusiasts so look after their car.
There can be lemons out there, but they do tend to have a sketchy past, like insurance write offs, so so long as you do proper checks or buy from a decent dealer, you should be good. Plenty of tuners, specialists around and forums like these, so if you are unfortunate to have a problem, it usually can be sorted without paying through the nose at the dealers.