I'm not being funny but it might be worth checking the fuel cap is on properly. I really don't trust the one on the A5 as it doesn't have the same "ratchet" system I had on the A3. It's hard to tell whether the cap is securely shut (on the A3 it used to click ... a bit like the childproof cap on a medicine bottle so you were assured it was sealed).
The other thing to do would be to get to a nice clear stretch of motorway, clear the average MPG on trip computer 1 and just cruise for about 30 miles or so. As others have posted, avoid rapid acceleration and you should be getting in the low 40's after about 30 miles.
Note when I say cruise I don't mean use the cruise control ... I'm sure this consumes more fuel but can't explain why. I've noticed this on all the cars I've had over the last 10 years or so. Clarkson also found it on the episode of Top Gear when he took an A6 (or was it A8?) from London to somewhere in the North and back on a single tank.
On the occassions I've averaged about 45mpg one of the key points is that I got into high gears ASAP, used only very gradual acceleration and made a real concious effort to drive with the flow of the traffic i.e. predict what's going to happen much earlier and take my foot off the gas to slow down, keeping off the brakes as much as possible. This sounds really anal but it's perfectly achievable to do this at between 70-80mph on the motorways outside rush hour and get 45mpg. I'm now convinced that if I were to go no higher than 60mph I could get close to 50mpg on a long motorway run with negligible in town driving (but who's going to pootle along at 60?)
One other tip is to make sure you're not carrying a lot of dead weight in the car. When I go on work trip I remove all the family crap from the car, mainly because I like my car tidy inside when it's just me but also because it's daft to be carrying an extra 40KG or so of car seats, books, spare clothes etc which I don't need.